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Antibodies to Malondialdehyde-Acetaldehyde Adduct Are Associated with Prevalent and Incident Rheumatoid Arthritis-Associated Interstitial Lung Disease in U.S. Veterans.

Nozima AripovaGeoffrey M ThieleMichael J DuryeeCarlos D HunterYangyuna YangPunyasha RoulDana P AschermanScott M MatsonGary KunkelGrant W CannonKatherine D WyshamGail S KerrPaul A MonachJoshua F BakerJill A PooleTed R MikulsBryant R England
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Protein-specific anti-MAA antibodies to collagen, fibrinogen, and vimentin were associated with prevalent RA-ILD. IgA and IgM anti-MAA-albumin antibodies were associated with a higher risk of incident RA-ILD. These findings suggest that MAA-modifications and resultant immune responses may contribute to RA-ILD pathogenesis.
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