Case series of nebulizing r-tPA for COVID-19 induced acute respiratory distress syndrome.
Shahideh AminiZohreh Labbani-MotlaghRasoul AliannejadSeyed Mohammad PourabbasMohammad VaseiPublished in: Clinical case reports (2022)
Fibrin deposition in the alveolar spaces during pulmonary involvement of COVID-19 impairs the O 2 /CO 2 exchange and leads to respiratory symptoms. In this report, Recombinant Tissue Plasminogen Activator (r-tPA) has been nebulized to 3 critically ill COVID-19 patients in order to resolve the deposited fibrin while avoiding the risk of bleeding. Based on these observations, nebulization of r-tPA may be a potential therapeutic approach and new area of research for future studies.
Keyphrases
- acute respiratory distress syndrome
- sars cov
- coronavirus disease
- extracorporeal membrane oxygenation
- mechanical ventilation
- respiratory syndrome coronavirus
- pulmonary hypertension
- high glucose
- diabetic rats
- atrial fibrillation
- current status
- drug induced
- sleep quality
- respiratory tract
- case control
- oxidative stress
- physical activity
- cell free