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NOD1 and NOD2 genetic variants: Impact on hepatocellular carcinoma susceptibility and progression in Moroccan population.

Chaimaa ZerradMustapha LkhiderMeryem BouqdayrAbdelkader BelkouchiWafaa BadreMohamed TahiriPascal PineauSoumaya BenjellounSayeh Ezzikouri
Published in: Gene (2024)
The NOD1 rs2075820 polymorphism does not appear to be a genetic risk factor for susceptibility to HCC. In contrast, the non-coding NOD2 rs718226 variant significantly increases HCC susceptibility and promotes liver cancer progression in the Moroccan population. Further studies involving larger cohorts are warranted to definitively confirm or refute the effects of NOD1 and NOD2 genetic variants on liver cancer susceptibility and progression.
Keyphrases
  • innate immune
  • magnetic resonance
  • genome wide
  • gene expression
  • computed tomography
  • case control