Andrographolide regulates H3 histone lactylation by interfering with p300 to alleviate aortic valve calcification.

Chunli WangShunshun WangZijun WangJuanjuan HanNan JiangLinghang QuKang Xu

Published in: British journal of pharmacology (2024)

Our findings, for the first time, demonstrated that AGP alleviates calcification by interfering with H3Kla via p300, which might be a powerful drug to prevent CAVD.

Keyphrases

aortic valve
transcatheter aortic valve replacement
aortic valve replacement
transcatheter aortic valve implantation
chronic kidney disease
aortic stenosis
dna methylation
mouse model
emergency department
gene expression
adverse drug
left ventricular