Nickel-Catalyzed Asymmetric Reductive Dicarbamoylation of Alkenes.

Published in: Organic letters (2021)

Herein we report a nickel-catalyzed asymmetric reductive dicarbamoylation of alkenes, in which tethered carbamoyl chlorides and isocyanates serve as distinct electrophilic carbamoylating agents, providing new access to chiral oxindoles bearing an amide-substituted quaternary stereogenic center.

Keyphrases

room temperature
reduced graphene oxide
oxide nanoparticles
solid state
carbon nanotubes
metal organic framework
molecular docking
capillary electrophoresis
mass spectrometry