Associations of Heavy Metals with Activities of Daily Living Disability: An Epigenome-Wide View of DNA Methylation and Mediation Analysis.

Lili XiaoHong ChengHaiqing CaiYue WeiGaohui ZanXiuming FengChaoqun LiuLongman LiLulu HuangFei WangXing ChenYunfeng ZouXiaobo Yang

Published in: Environmental health perspectives (2022)

Our findings suggested that heavy metals contributed to higher prevalence of ADL disability and that locus-specific DNA methylation are partial mediators, providing potential biomarkers for further cellular mechanism studies. https://doi.org/10.1289/EHP10602.

Keyphrases

dna methylation
heavy metals
genome wide
risk assessment
multiple sclerosis
gene expression
health risk assessment
health risk
sewage sludge
risk factors
copy number
case control
depressive symptoms