Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer.

Bohai FengYing ShenXavier Pastor HostenchMatthias BiegMichaela PlathNaveed IshaqueRoland EilsKolja FreierWilko WeichertKarim ZaouiJochen Hess

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Our data highlight a complex interplay between genetic and epigenetic events in the establishment of the tumor immune phenotype and provide compelling experimental evidence that a patient with squamous cell carcinoma of the head and neck at higher risk for ICI treatment failure might benefit from a combination with EGFR inhibition.

Keyphrases

small cell lung cancer
squamous cell carcinoma
epidermal growth factor receptor
electronic health record
tyrosine kinase
big data
dna methylation
gene expression
case report
genome wide
radiation therapy
copy number
sentinel lymph node
early stage
lymph node metastasis