The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain.
Abdul-Raouf IssaJun SunCéline PetitgasAna MesquitaAmina DulacMarion RobinBertrand MollereauAndreas JennyBaya Chérif-ZaharSerge BirmanPublished in: Autophagy (2018)
Act5C: actin 5C; a.E.: after eclosion; Atg5: autophagy-related 5; Atg8a/LC3: autophagy-related 8a; CMA: chaperone-mediated autophagy; DHE: dihydroethidium; elav: embryonic lethal abnormal vision; eMI: endosomal microautophagy; ESCRT: endosomal sorting complexes required for transport; GABARAP: GABA typeA receptor-associated protein; Hsc70-4: heat shock protein cognate 4; HSPA8/Hsc70: heat shock protein family A (Hsp70) member 8; LAMP2: lysosomal associated membrane protein 2; MDA: malondialdehyde; PA-mCherry: photoactivable mCherry; PBS: phosphate-buffered saline; PCR: polymerase chain reaction; PD: Parkinson disease; Ref(2)P/p62: refractory to sigma P; ROS: reactive oxygen species; RpL32/rp49: ribosomal protein L32; RT-PCR: reverse transcription polymerase chain reaction; SING: startle-induced negative geotaxis; SNCA/α-synuclein: synuclein alpha; SQSTM1/p62: sequestosome 1; TBS: Tris-buffered saline; UAS: upstream activating sequence.
Keyphrases
- heat shock protein
- parkinson disease
- cell death
- heat shock
- deep brain stimulation
- reactive oxygen species
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- diabetic rats
- high glucose
- drug induced
- cell cycle arrest
- loop mediated isothermal amplification
- dna damage
- cell proliferation
- amino acid
- resting state
- pi k akt
- binding protein
- mass spectrometry
- simultaneous determination
- physical activity
- quantum dots
- protein protein
- sensitive detection