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A Novel Rheumatic Mitral Valve Disease Model with Ex Vivo Hemodynamic and Biomechanical Validation.

Matthew H ParkPearly K PandyaYuanjia ZhuDanielle M MullisHanjay WangAnnabel M Imbrie-MooreRobert WilkersonMateo Marin-CuartasYiping Joseph Woo
Published in: Cardiovascular engineering and technology (2022)
This work represents the creation of the first ex vivo model of rheumatic MV disease, bearing close similarity to the human pathophysiology and hemodynamics, and it will be used to extensively study both established and new treatment techniques, benefitting the millions of affected victims.
Keyphrases
  • mitral valve
  • rheumatoid arthritis
  • endothelial cells
  • multidrug resistant
  • left atrial
  • induced pluripotent stem cells
  • left ventricular
  • smoking cessation
  • replacement therapy
  • catheter ablation