Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein.
Troels Elmer JeppesenJesper B KristensenCarsten BehrensJacob MadsenAndreas KjaerPublished in: Journal of labelled compounds & radiopharmaceuticals (2021)
New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.