Reconciling egg- and antigen-based estimates of Schistosoma mansoni clearance and reinfection: a modelling study.
Jessica ClarkMoses ArinaitweAndrina NankasiChristina L FaustAdriko MosesDiana AjamboFred BesigyeAlon AtuhaireAidah WambokoLauren V CarruthersRachel FrancoeurEdridah M TukahebweJoaquin M PradaPoppy H L LambertonPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Treatment impact was shorter-lived than only Kato-Katz-based estimates suggested, with lower clearance and rapid reinfection. Three-weeks-post-treatment captured longer-term clearance dynamics. Nine-weeks-post-treatment captured reinfection, but alone could not discern between failed clearance and rapid reinfection. Therefore, frequent sampling is required to understand these important epidemiological dynamics.
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