Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis.
Lael M YonkerZoe SwankYannic C BartschMadeleine D BurnsAbigail KaneBrittany P BoribongJameson P DavisMaggie LoiselleTanya NovakYasmeen SenussiChi-An ChengEleanor BurgessAndrea G EdlowJanet ChouAudrey DionneDuraisamy BalaguruManuella Lahoud-RahmeMoshe ArditiBoris JulgAdrienne G RandolphGalit AlterAlessio FasanoDavid R WaltPublished in: Circulation (2023)
Immunoprofiling of vaccinated adolescents and young adults revealed that the mRNA vaccine-induced immune responses did not differ between individuals who developed myocarditis and individuals who did not. However, free spike antigen was detected in the blood of adolescents and young adults who developed post-mRNA vaccine myocarditis, advancing insight into its potential underlying cause.