SARS-CoV-2 spike protein-mediated cardiomyocyte fusion may contribute to increased arrhythmic risk in COVID-19.

Daniel J ClemensDan YeWei ZhouC S John KimDavid R PeaseChanakha K NavaratnarajahAlison BarkhymerDavid J TesterTimothy J NelsonRoberto CattaneoJay W SchneiderMichael J Ackerman

Published in: PloS one (2023)

The SARS-CoV-2 spike protein can directly perturb both the cardiomyocyte's repolarization reserve and intracellular calcium handling that may confer the intrinsic, mechanistic substrate for the increased risk of SCD observed during this COVID-19 pandemic.

Keyphrases

sars cov
respiratory syndrome coronavirus
amino acid
protein protein
angiotensin ii
coronavirus disease
binding protein
small molecule
reactive oxygen species
high glucose
endothelial cells