The role of cellular senescence in profibrillatory atrial remodelling associated with cardiac pathology.

Mozhdeh MehdizadehPatrice NaudIssam H Abu-TahaRoddy HiramFeng XiongJiening XiaoArnela SaljicMarkus KamlerNhung Vuong-RobillardÉric Thorin Gerardo Ferbeyre Jean Claude TardifMartin G SiroisJean Francois TanguayDobromir Dobrev Stanley Nattel

Published in: Cardiovascular research (2024)

Our results point to a potentially significant role of cellular senescence in AF pathophysiology. Modulating cell senescence might provide a basis for novel therapeutic approaches to AF.

Keyphrases

atrial fibrillation
dna damage
endothelial cells
stress induced
single cell
left ventricular
oxidative stress
stem cells
mesenchymal stem cells
catheter ablation