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PanoromiX: a time-course network medicine platform integrating molecular assays and pathophenotypic data.

Ruoting YangDaniel WatsonJoshua WilliamsRaina KumarRoss CampbellUma MudunuriRasha HammamiehMarti Jett
Published in: BMC bioinformatics (2018)
This emergent tool of network medicine is the first to visualize the interconnectedness of tailored genome assays to pathological networks and phenotypes for cells or organisms in a data-agnostic manner. As an advanced network medicine tool, PanoromiX allows monitoring of panel of biomarker perturbations over the progression of diseases, disease classification based on changing network modules that corresponds to specific patho-phenotype as opposed to clinical symptoms, systematic exploration of complex molecular interactions and distinct disease states via regulatory network changes, and the discovery of novel diagnostic and therapeutic targets.
Keyphrases
  • high throughput
  • electronic health record
  • induced apoptosis
  • transcription factor
  • oxidative stress
  • cell death
  • signaling pathway
  • gram negative