Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study.
Isabella C SchoepfChristian W ThorballBruno LedergerberTanja EngelMarieke RaffenbergNeeltje A KootstraPeter ReissBarbara HasseCatia MarzoliniChristine ThurnheerMarco SeneghiniEnos BernasconiMatthias CavassiniHélène BuvelotRoger KouyosHuldrych F GünthardJacques FellayPhilip E Tarrnull nullPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
In Swiss PLWH, CAD prediction based on traditional and HIV-related risk factors was superior to genetic CAD prediction based on longevity- and CAD-associated PRS. Combining traditional, HIV-related, and genetic risk factors provided the most powerful CAD prediction.
Keyphrases
- coronary artery disease
- human immunodeficiency virus
- antiretroviral therapy
- hepatitis c virus
- hiv infected
- risk factors
- hiv positive
- hiv aids
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular events
- hiv testing
- men who have sex with men
- type diabetes
- cardiovascular disease
- drug induced
- atrial fibrillation
- left ventricular
- aortic valve