Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations.
Patrick P LoweCaroline MorelAditya AmbadeArvin Iracheta-VellveErica KwiatkowskiAbhishek SatishchandranIstvan FuriYeonhee ChoBenedek GyongyosiDonna CatalanoEric LefebvreLaurent FischerStar SeyedkazemiDorothy P SchaferGyongyi SzaboPublished in: Journal of neuroinflammation (2020)
Together, our data establish that chronic alcohol consumption promotes the recruitment of peripheral macrophages into the CNS and microglia alterations through the CCR2/5 axis. Therefore, further exploration of the CCR2/5 axis as a modulator of neuroinflammation may offer a potential therapeutic approach for the treatment of alcohol-associated neuroinflammation.
Keyphrases
- alcohol consumption
- lipopolysaccharide induced
- inflammatory response
- lps induced
- traumatic brain injury
- dendritic cells
- regulatory t cells
- cognitive impairment
- cerebral ischemia
- neuropathic pain
- drug induced
- chemotherapy induced
- adipose tissue
- blood brain barrier
- diabetic rats
- high glucose
- electronic health record
- immune response
- spinal cord injury
- oxidative stress
- machine learning
- brain injury
- smoking cessation