Intra-articular vs. intravenous administration: a meta-analysis of tranexamic acid in primary total knee arthroplasty.

Intra-articular administration of TXA is superior to intravenous in primary TKA patients regarding the performance on TBL, drain output, and POD3+ Hb fall, without increased risk of perioperative complications. Therefore, intra-articular administration is the recommended approach in clinical practice for primary TKA.