Decitabine shows potent anti-myeloma activity by depleting monocytic myeloid-derived suppressor cells in the myeloma microenvironment.

Jihao ZhouQi ShenHaiqing LinLina HuGuoqiang LiXinyou Zhang

Published in: Journal of cancer research and clinical oncology (2018)

DAC treatment can inhibit myeloma cell proliferation and induce enhanced autologous T cell immune response by depleting M-MDSCs in the MM microenvironment. We believe that DAC treatment could improve the prognosis of MM in future.

Keyphrases

immune response
cell proliferation
multiple myeloma
stem cells
induced apoptosis
acute myeloid leukemia
bone marrow
combination therapy
mesenchymal stem cells
cell cycle
signaling pathway
oxidative stress
cell death
cell therapy
anti inflammatory