Quantification of Unencapsulated Drug in Target Tissues Demonstrates Pharmacological Properties and Therapeutic Effects of Liposomal Topotecan (FF-10850).

Toshifumi KimuraKen OkadaYasushi MorohashiYukio KatoMikinaga MoriHiroshi KatoTakeshi MatsumotoSusumu Shimoyama

Published in: Pharmaceutical research (2024)

Tissue pharmacokinetics of unencapsulated topotecan elucidated the favorable pharmacological properties of FF-10850. Evaluation of tissue exposure to an unencapsulated drug with appropriate pharmacodynamic markers can be valuable in optimizing liposomal drugs and dosing regimens.

Keyphrases

gene expression
drug induced
emergency department
electronic health record