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Targeted combined therapy in 2D and 3D cultured MCF-7 cells using metformin and erlotinib-loaded mesoporous silica magnetic nanoparticles.

Nastaran HashemzadehAyuob AghanejadElaheh Dalir AbdolahiniaMitra DolatkhahMohammad Barzegar-JalaliYadollah OmidiMorteza MahmoudiKhosro Adibkia
Published in: Journal of microencapsulation (2021)
Overall, our combined ER and MET-loaded targeted NSs result in a synergistic inhibitory impact on MCF-7 cells.
Keyphrases
  • cancer therapy
  • induced apoptosis
  • cell cycle arrest
  • breast cancer cells
  • drug delivery
  • magnetic nanoparticles
  • endoplasmic reticulum stress
  • cell death
  • stem cells
  • advanced non small cell lung cancer
  • pi k akt