Neutrophil dysfunction due to continuous mechanical shear exposure in mechanically assisted circulation in vitro.

Wenji SunJiafeng ZhangAakash ShahKatherin Arias Zachary B K BerkBartley P GriffithZhongjun Jon Wu

Published in: Artificial organs (2021)

Our study revealed that the pump-assisted circulation induced neutrophil activation, apoptosis, and functional impairment. The alterations were strongly associated with pump operating condition and duration.

Keyphrases

oxidative stress
diabetic rats
endoplasmic reticulum stress
cell death
single cell
drug induced
cell proliferation