Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma.
Mikhail KondrashovSamuel P S SvenssonPeter StrömAndreas WestermarkHanna Jacobson-IngemyrAkihiro TakanoLenke TariMiklós TóthMinying CaiVictor J HrubyMagnus SchouPublished in: Bioconjugate chemistry (2021)
A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.
Keyphrases
- pet imaging
- positron emission tomography
- high resolution
- living cells
- computed tomography
- quantum dots
- induced apoptosis
- single molecule
- type diabetes
- metabolic syndrome
- energy transfer
- skin cancer
- pet ct
- high fat diet induced
- binding protein
- mass spectrometry
- transcription factor
- basal cell carcinoma
- oxide nanoparticles