Identification of Genes with Rare Loss of Function Variants Associated with Aggressive Prostate Cancer and Survival.

Edward J SaundersTokhir DadaevMark N BrookSarah WakerellKoveela GovindasamiReshma RageevakumarNafisa HussainAndrea OsborneDiana KeatingArtitaya LophatananonKenneth R Muirnull nullBurcu F DarstDavid V ContiChristopher A HaimanAntonis C AntoniouRosalind A EelesZsofia Kote-Jarai

Published in: European urology oncology (2024)

By combining data from several previous studies, we have been able to enhance knowledge regarding genes in which inherited mutations would be expected to increase the risk of more aggressive PrCa. This may, in the future, aid in the identification of men at an elevated risk of dying from PrCa.

Keyphrases

bioinformatics analysis
prostate cancer
genome wide
healthcare
palliative care
radical prostatectomy
genome wide identification
electronic health record
copy number
current status
big data
dna methylation
machine learning
free survival
genome wide analysis
data analysis