Genetic footprints of assortative mating in the Japanese population.
Kenichi YamamotoKyuto SoneharaShinichi NambaTakahiro KonumaHironori MasukoSatoru Miyawakinull nullYoichiro KamataniNobuyuki HizawaKeiichi OzonoLoic YengoYukinori OkadaPublished in: Nature human behaviour (2022)
Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations.
Keyphrases
- electronic health record
- type diabetes
- coronary artery disease
- genome wide
- big data
- machine learning
- adipose tissue
- hiv testing
- metabolic syndrome
- data analysis
- coronary artery bypass grafting
- gene expression
- percutaneous coronary intervention
- rna seq
- copy number
- hiv infected
- deep learning
- transcatheter aortic valve replacement
- aortic valve