Methionine oxidation of CLK4 promotes the metabolic switch and redox homeostasis in esophageal carcinoma via inhibiting MITF selective autophagy.

Yaxing ShenHeng ZhangShihua YaoFeng SuHao WangJun YinYong FangLijie TanKaiguang ZhangXiangshan FanMing ZhongQingxin ZhouJie HeZhiyong Zhang

Published in: Clinical and translational medicine (2022)

Our data highlight the potential role of CLK4 in modulating redox status and nucleotide metabolism, suggesting potential therapeutic targets in ESCC treatment.

Keyphrases

signaling pathway
oxidative stress
electronic health record
machine learning
combination therapy
deep learning
smoking cessation
replacement therapy