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Origins of biallelic inactivation of NF2 in neurofibromatosis type 2.

Lu XueWeiwei HeYi ZhangZhigang WangHongsai ChenZhe ChenWeidong ZhuDongmei LiuHuan JiaYi JiangZhaoyan WangHao Wu
Published in: Neuro-oncology (2022)
Our results suggested that biallelic inactivation of NF2 evolved through neutral drift and preexisting first hit NF2 allele determines certain aspects of the clinical symptoms. Genetic diagnosis should be included in the diagnostic criteria and treatment consideration of NF2.
Keyphrases
  • signaling pathway
  • lps induced
  • pi k akt
  • nuclear factor
  • oxidative stress
  • intellectual disability
  • inflammatory response
  • genome wide
  • gene expression
  • autism spectrum disorder
  • immune response
  • physical activity