Prediction of fulvestrant efficacy in patients with advanced breast cancer: retrospective-prospective evaluation of the predictive potential of a multigene expression assay.

Troels Dreier ChristensenAnna Sofie Kappel BuhlIb Jarle ChristensenIda Kappel BuhlEva BalslevAnn S KnoopHella DanøVesna GlavicicAdam LuczakSven Tyge LangkjerSøren LinnetErik Hugger JakobsenJurij BogovicBent EjlertsenAnnie RasmussenAnker HansenSteen KnudsenPeter Buhl JensenDorte Nielsen

Published in: Breast cancer (Tokyo, Japan) (2019)

The DRP showed a potential in predicting fulvestrant treatment but was not significant in the overall analysis. Use of older biopsies, long-term endocrine treatment and multiple therapies between biopsy used for analysis and fulvestrant treatment, probably affect the predictive accuracy.

Keyphrases

risk assessment
physical activity
high throughput
combination therapy
metastatic breast cancer
middle aged
human health
data analysis
community dwelling