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Biologically informed NeuralODEs for genome-wide regulatory dynamics.

Intekhab HossainViola FanfaniJonas FischerJohn QuackenbushRebekka Burkholz
Published in: Genome biology (2024)
PHOENIX uses a combination of user-defined prior knowledge and functional forms from systems biology to encode biological "first principles" as soft constraints on the GRN allowing us to predict subsequent gene expression patterns in a biologically explainable manner.
Keyphrases
  • gene expression
  • genome wide
  • dna methylation
  • healthcare
  • transcription factor