Biologically informed NeuralODEs for genome-wide regulatory dynamics.
Intekhab HossainViola FanfaniJonas FischerJohn QuackenbushRebekka BurkholzPublished in: Genome biology (2024)
PHOENIX uses a combination of user-defined prior knowledge and functional forms from systems biology to encode biological "first principles" as soft constraints on the GRN allowing us to predict subsequent gene expression patterns in a biologically explainable manner.