Effect of Genetic and Dietary Perturbation of Glycine Metabolism on Atherosclerosis in Humans and Mice.

Subarna BiswasJames R HilserNicholas C WoodwardZeneng WangJanet GukasyanIna NemetWilliam S SchwartzmanPin HuangYi HanZachary FouladianSarada CharugundlaNeal J SpencerCalvin PanWai Hong Wilson Tang Aldons J Lusis Stanley L Hazen Jaana A Hartiala Hooman Allayee

Published in: medRxiv : the preprint server for health sciences (2023)

feeding studies in humans and mice, respectively, did not provide evidence that the clinical association of this amino acid with CAD represents a causal relationship, despite being associated with two correlated risk factors.

Keyphrases

risk factors
amino acid
high fat diet induced
cardiovascular disease
genome wide
type diabetes
wild type
metabolic syndrome
gene expression
adipose tissue
dna methylation
case control
copy number