Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?
Dominika PietrzykPiotr TkaczMateusz KozłowskiSebastian KwiatkowskiMałgorzata RychlickaEwa Pius-SadowskaBogusław MachalińskiAneta Cymbaluk-PłoskaPublished in: International journal of environmental research and public health (2023)
Obesity and being overweight are risk factors for many types of cancer, including endometrial cancer. Adipose tissue is thought to be an endocrine organ that produces various hormones, including one known as vaspin. Insulin resistance, metabolic syndrome and type 2 diabetes are all associated with higher vaspin levels. A total of 127 patients divided into study (endometrial cancer) and control groups (non-cancerous) participated in this research. Serum vaspin levels were measured for all patients. The analysis was performed while taking into account grading and staging. In order to assess the usefulness of the tested protein as a new diagnostic marker, we used the plotting of a curve (ROC) and the calculation of the AUC curve to characterize the sensitivity and specificity of the parameters tested. We concluded that there were significantly lower vaspin levels in patients with endometrial cancer compared to patients with benign endometrial lesions. Vaspin may be a useful diagnostic marker in separating benign lesions from endometrial cancer.
Keyphrases
- endometrial cancer
- insulin resistance
- metabolic syndrome
- type diabetes
- end stage renal disease
- adipose tissue
- chronic kidney disease
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- skeletal muscle
- weight loss
- high fat diet
- climate change
- high fat diet induced
- physical activity
- small molecule
- risk assessment
- papillary thyroid
- polycystic ovary syndrome
- uric acid