Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction.

Paola Miranda SulisBetina Fernanda DambrósAlessandra MascarelloAdair Roberto Soares Dos SantosRosendo Augusto YunesRicardo José NunesMarisa Jádna Silva FredericoFátima Regina Mena Barreto Silva

Published in: Journal of cellular physiology (2018)

SD diminish glycemia by inducing GLP-1 secretion and inhibiting disaccharidases. To our knowledge, this is the first report of an insulin secretagogue effect of SD that is mediated by potassium and calcium, as well as sodium, signal transduction.

Keyphrases

type diabetes
healthcare
signaling pathway
metabolic syndrome
adipose tissue