Small airway dysfunction as predictor and marker for clinical response to biological therapy in severe eosinophilic asthma: a longitudinal observational study.

Mustafa AbdoHenrik WatzVera VeithAnne-Marie KirstenHeike BillerFrauke PedersenErika von MutiusMatthias V KoppGesine HansenBenjamin WaschkiKlaus F RabeFrederik TrinkmannThomas Bahmer

Published in: Respiratory research (2020)

Our data suggest that severe SAD may represent a distinct phenotype of eosinophilic asthma that substantially improves under anti-T2 biological therapy. Measures of small airway function might be useful in selecting appropriate patients qualifying for anti-T2 biological therapy in addition to blood eosinophil count.

Keyphrases

end stage renal disease
chronic obstructive pulmonary disease
chronic kidney disease
lung function
early onset
ejection fraction
peritoneal dialysis
machine learning
electronic health record
patient reported outcomes
mesenchymal stem cells
deep learning
patient reported