Serum GFAP differentiates Alzheimer's disease from frontotemporal dementia and predicts MCI-to-dementia conversion.
Patrick OecklSarah Anderl-StraubChristine A F Von ArnimInês BaldeirasJanine Diehl-SchmidTimo GrimmerSteffen HalbgebauerAnna M De KortMarisa LimaTainá M MarquesMarion OrtnerIsabel SantanaPetra SteinackerMarcel M VerbeekAlexander E VolkAlbert C LudolphMarkus OttoPublished in: Journal of neurology, neurosurgery, and psychiatry (2022)
Our data indicate a different type of reactive astrogliosis in AD and bvFTD and support serum GFAP as biomarker for differential diagnosis and prediction of MCI-to-dementia conversion.