Autophagy in the heart is enhanced and independent of disease progression in mus musculus dystrophinopathy models.

H R SpauldingC BallmannJohn C QuindryM B HudsonJoshua T Selsby

Published in: JRSM cardiovascular disease (2019)

Together these data suggest that autophagy is not impaired in the dystrophic myocardium as it is in dystrophic skeletal muscle and that disease progression and related injury is independent of autophagic dysfunction.

Keyphrases

cell death
skeletal muscle
oxidative stress
endoplasmic reticulum stress
signaling pathway
heart failure
insulin resistance
electronic health record
big data
atrial fibrillation
type diabetes
adipose tissue
metabolic syndrome