Quantifying and reducing spurious alignments for the analysis of ultra-short ancient DNA sequences.

Cesare de FilippoMatthias MeyerKay Prüfer

Published in: BMC biology (2018)

Our method maximizes the sequence data amenable to genetic analysis from highly degraded ancient material and avoids pitfalls that are associated with the analysis of ultra-short DNA sequences.

Keyphrases

circulating tumor
cell free
single molecule
high resolution
electronic health record
nucleic acid
big data
data analysis
deep learning