The TP53 p.R337H mutation is uncommon in a Brazilian cohort of pediatric patients diagnosed with ependymoma.
Taciani de Almeida MagalhãesKleiton Silva BorgesGraziella Ribeiro de SousaSilvia Regina BrandaliseAna Luiza SeidingerCarlos Alberto ScrideliSueli Mieko Oba-ShinjoJosé Andrés YunesLuiz Gonzaga TonePublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2019)
The present finding indicates that the TP53 p.R337H germline mutation is uncommon in patients with EPN in Brazil and screening of pediatric patients RELA fusion EPN may be informative to better understand the role of TP53 germline mutations in the development and prognosis of these tumors.
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