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Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity.

Jana MaříkováEliška KohelováDarina MuthnáJiří KunešRadim HavelekRudolf VrabecMilan MalanikDaniela SuchánkováJakub ChlebekJaroslav JencoŠtefan KosturkoLucie Cahlíková
Published in: Journal of natural products (2024)
This phytochemical study presents the isolation of eight alkaloids from Zephyranthes citrina Baker. The structures of the new alkaloids, zephycitrine ( 1 ) and 6-oxonarcissidine ( 2 ), were established by analysis of spectroscopic and spectrometric data. Processing the EtOH extract under acid-base conditions yielded the unreported isolation artifacts 3 and 4 . This work also provides analytical data for alkaloids not properly described in the literature ( 5 and 6 ). The hippeastidine/zephyranine scaffolds in derivatives 3 , 4 , and 8 - 10 are also thoroughly discussed. Furthermore, a cytotoxicity screening of 25 Amaryllidaceae alkaloids isolated from Z. citrina was performed. Only the known alkaloids haemanthamine ( 12 ), haemanthidine ( 13 ), and lycorine ( 27 ) showed significant cell growth inhibition.
Keyphrases
  • electronic health record
  • systematic review
  • big data
  • liquid chromatography
  • computed tomography
  • magnetic resonance
  • mass spectrometry
  • ms ms
  • high performance liquid chromatography
  • structure activity relationship