Intravitreal and subretinal syngeneic bone marrow mononuclear stem cell transplantation improves photoreceptor survival but does not ameliorate retinal function in two rat models of retinal degeneration.
Johnny Di PierdomenicoAlejandro Gallego-OrtegaAna Martínez-VacasDavid García-BernalManuel Vidal-SanzMaría P Villegas-PérezDiego García-AyusoPublished in: Acta ophthalmologica (2022)
Intravitreal and subretinal syngeneic BM-MNCs transplantation decreases photoreceptor degeneration and shows anti-gliotic effects on Müller cells but does not ameliorate retinal function. Moreover, syngeneic BM-MNCs transplants are more effective than the xenotransplants of these cells. BM-MNC transplantation has potential therapeutic effects that merit further investigation.
Keyphrases
- diabetic retinopathy
- stem cell transplantation
- induced apoptosis
- optical coherence tomography
- bone marrow
- cell cycle arrest
- vascular endothelial growth factor
- oxidative stress
- optic nerve
- endoplasmic reticulum stress
- cell therapy
- mesenchymal stem cells
- signaling pathway
- stem cells
- low dose
- age related macular degeneration