Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response.
Yi-Na WangYuan-Yuan WangJin WangWen-Juan BaiNai-Jun MiaoJing WangPublished in: Journal for immunotherapy of cancer (2023)
This study explored whether manipulating cellular morphology affects macrophage polarization and consequently induces an antitumor response. Our data reveal a previously unrecognized antitumor mechanism of VBL and suggest a drug repurposing strategy combining VBL with immune checkpoint inhibitors to improve malignant tumor immunotherapy.