Carbon Monoxide-Releasing Molecule-3 Enhances Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells via miR-195-5p/Wnt3a Pathway.

Jingyuan LiQingbin HanHui ChenTingting LiuJiahui SongMeng HouLingling WeiHui Song

Published in: Drug design, development and therapy (2022)

These results demonstrate that CORM-3 promoted osteogenic differentiation of rat BMSCs via miR-195-5p/Wnt3a, which bodes well for the application of CORM-3 in the treatment of periodontal disease and other bone-defect diseases.

Keyphrases

stem cells
cell proliferation
oxidative stress
bone mineral density
soft tissue
postmenopausal women
bone loss