Detection of circulating tumor DNA with ultradeep sequencing of plasma cell-free DNA for monitoring minimal residual disease and early detection of recurrence in early-stage lung cancer.
Aaron C TanGillianne G Y LaiStephanie P L SawKevin L M ChuaAngela TakanoBoon-Hean OngTina P T KohAmit JainWan Ling TanQuan Sing NgRavindran KanesvaranTanujaa RajasekaranEkaterina KalashnikovaDerrick RennerSumedha SudhamanMeenakshi MalhotraHimanshu SethiMinetta C LiuAlexey AleshinWan-Teck LimEng-Huat TanAnders J SkanderupMei-Kim AngDaniel S W TanPublished in: Cancer (2024)
ctDNA detection before surgical resection was strongly associated with a high risk of relapse in early-stage NSCLC in a large unique Asian cohort. Prospective studies are needed to assess the clinical utility of ctDNA status in this setting.