In vivo Characterization of the Opioid Receptor-Binding Profiles of Samidorphan and Naltrexone in Rats: Comparisons at Clinically Relevant Concentrations.

Laura A TanNileshkumar GajiparaLei SunMaria BacolodYing ZhouMark N NamchukJacobi I Cunningham

Published in: Neuropsychiatric disease and treatment (2022)

At clinically relevant concentrations, samidorphan occupied MOR, DOR, and KOR, whereas naltrexone occupied only MOR and KOR. The binding profile of samidorphan differs from that of naltrexone, with potential clinical implications.

Keyphrases

alcohol use disorder
binding protein
chronic pain
dna binding
pain management