Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway.

Al-Aliaa M SallamSamar F DarwishWalaa A El-DakrouryEman Radwan

Published in: Pharmaceutical research (2021)

We explored OLM anti-ulcerative effects, implicating oxidative stress and inflammation improvement, mediated by the Nrf2/HO-1 signaling pathway and p38-MAPK translocation. Meanwhile, the more bioavailable OLM-NIO achieved better gastro-protective effects compared to conventional OLM form.

Keyphrases

oxidative stress
pi k akt
signaling pathway
diabetic rats
induced apoptosis
ischemia reperfusion injury
dna damage
epithelial mesenchymal transition
cell proliferation
high glucose
mouse model
endothelial cells