Interleukin-6 and interferon-alpha differentially regulate microglia function.

Rovin VerdilloAlanna SpiteriBarney ViengkhouClaire WishartNicholas J C KingMarkus J Hofer

Published in: Neuropathology and applied neurobiology (2024)

Previous reports have shown that IL-6 and IFN-⍺ induce distinct transcriptomic and morphological changes in microglia. Here, we demonstrate that IL-6 increases tissue surveillance, migration and phagocytosis in primary murine microglia, whereas IFN-⍺ inhibits these functions. Our results provide a crucial link between transcriptome and function. It holds the potential to serve as the foundation for future studies aimed at identifying therapeutic targets for cytokine-mediated neuroinflammatory diseases.

Keyphrases

inflammatory response
dendritic cells
neuropathic pain
single cell
immune response
rna seq
gene expression
current status
genome wide
emergency department
spinal cord
spinal cord injury
dna methylation
adverse drug
climate change
risk assessment
electronic health record