Choledocholithiasis Can Present with Marked Transaminases Elevation: Systematic Review and Meta-Analysis.

Mouhand Faisal Hamad MohamedKhaled ElfertNeha WadhavkarDaniel MarinoKanhai FarrakhanAzizullah BeranMohamed A AbdallahAbubaker AbdallaRonan Farrell

Published in: Digestive diseases and sciences (2023)

This is the first meta-analysis to study prevalence of severe hepatocellular injury in patients with CBD stones. Results revealed that approximately one-third of patients with choledocholithiasis present with ALT or AST > 500 IU/L. Furthermore, levels > 1000 IU/L are not uncommon. An elaborate work-up for alternative etiologies of severe transaminase elevation is likely unwarranted in cases with clear evidence of choledocholithiasis.

Keyphrases

systematic review
early onset
risk factors
meta analyses
drug induced