The Molecular Landscape of Pancreatobiliary Cancers for Novel Targeted Therapies From Real-World Genomic Profiling.

Kumiko UmemotoHiroyuki YamamotoRitsuko OikawaHiroyuki TakedaAyako DoiYoshiki HorieHiroyuki AraiTakashi OguraTakuro MizukamiNaoki IzawaJay A MooreEthan S SokolYu Sunakawa

Published in: Journal of the National Cancer Institute (2022)

We identified an appreciable frequency of immunotherapy biomarkers and targetable gene alterations in both PC and BTC, with notable frequencies in PC samples lacking KRAS mutations and children or adolescent and young adult populations, that should encourage comprehensive genomic profiling testing.

Keyphrases

young adults
copy number
single cell
childhood cancer
genome wide
mental health
dna methylation
transcription factor