Greater Diffusion Restriction in White Matter in Preclinical Alzheimer Disease.
Andreana BenitezJens H JensenKathryn ThornSiddhartha DhimanStephanie Fountain-ZaragozaWilliam J RieterMaria Vittoria SpampinatoEric D HamlettPaul J NietertMaria de Fatima FalangolaJoseph A HelpernPublished in: Annals of neurology (2022)
These results support prior evidence of a nonmonotonic change in diffusion behavior, where an early increase in diffusion restriction is hypothesized to reflect inflammation and myelin repair prior to an ensuing decrease in diffusion restriction, indicating glial and neuronal degeneration. ANN NEUROL 2022;91:864-877.