KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma.
Jonas CicenasLinas TamosaitisKotryna KvederaviciuteRicardas TarvydasGintare StaniuteKarthik KalyanEdita Meskinyte-KausilieneVaidotas StankeviciusMindaugas ValiusPublished in: Medical oncology (Northwood, London, England) (2017)
Cancers are the group of diseases, which arise because of the uncontrolled behavior of some of the genes in our cells. There are possibilities of gene amplifications, overexpressions, deletions and other anomalies which might lead to the development and spread of cancer. One of the most dangerous ways to the cancers is the mutations of the genes. The mutated genes can start unstoppable proliferation of cells, their uncontrolled motility, protection from apoptosis, the DNA mutation enhancement as well as other anomalies, leading to the cancer. This review focuses on the genes, which are frequently mutated in various cancers and are known to be important in the advance and progression of colorectal cancer and melanoma, namely KRAS, NRAS and BRAF.
Keyphrases
- wild type
- cell cycle arrest
- genome wide
- genome wide identification
- induced apoptosis
- papillary thyroid
- bioinformatics analysis
- cell death
- genome wide analysis
- endoplasmic reticulum stress
- childhood cancer
- oxidative stress
- dna methylation
- signaling pathway
- pi k akt
- gene expression
- lymph node metastasis
- cell proliferation
- pseudomonas aeruginosa
- metastatic colorectal cancer
- cell free
- staphylococcus aureus
- young adults