An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.

Yifei ChengLang WuJunyi XinShuai BenSilu ChenHuiqin LiLingyan ZhaoMeilin WangGong ChengMulong Du

Published in: Journal of translational medicine (2024)

This study comprehensively profiled the distinct genetic and phenotypic architecture of EOPC. The EOPC-PRS may optimize risk estimate of PCa in young males, particularly those without family history, thus providing guidance for precision population stratification.

Keyphrases

early onset
prostate cancer
late onset
genome wide
gene expression
middle aged